BDBM50162020 3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-5-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-6-methyl-1H-pyrimidine-2,4-dione::CHEMBL359754

SMILES Cc1c(-c2ccc3OCCOc3c2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1F

InChI Key InChIKey=KSMPQSVSWDXWJN-QHCPKHFHSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50162020   

TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162020(3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-ben...)
Affinity DataKi:  5.10nMAssay Description:Binding affinity for Human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162020(3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-ben...)
Affinity DataKi:  74nMAssay Description:Binding affinity for Monkey gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162020(3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-ben...)
Affinity DataKi:  1.80E+4nMAssay Description:Binding affinity for Rat gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162020(3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-ben...)
Affinity DataIC50:  10nMAssay Description:Inhibition of Human gonadotropin-releasing hormone receptor stimulated calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed