BDBM50162627 1,3-Diamino-7-hydroxy-9,9a-dihydro-4aH-xanthene-2-carbonitrile::CHEMBL180959

SMILES NC1=C(C#N)C(=N)CC2Oc3ccc(O)cc3CC12

InChI Key InChIKey=PJOMLFPVVDPQMV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50162627   

TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50162627(1,3-Diamino-7-hydroxy-9,9a-dihydro-4aH-xanthene-2-...)
Affinity DataIC50:  2.54E+4nMAssay Description:Inhibition of TNFalpha expression in U937 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50162627(1,3-Diamino-7-hydroxy-9,9a-dihydro-4aH-xanthene-2-...)
Affinity DataIC50:  470nMAssay Description:Concentration of 50% inhibition by compound towards mitogen activated protein kinase -activated protein kinase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed