BDBM50162637 1,3-Diamino-6-[1,4]dioxan-2-yl-7-hydroxy-9,9a-dihydro-4aH-xanthene-2-carbonitrile::CHEMBL178413

SMILES NC1=C(C#N)C(=N)CC2Oc3cc(C4COCCO4)c(O)cc3CC12

InChI Key InChIKey=WGBIXNYWULDFON-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50162637   

TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50162637(1,3-Diamino-6-[1,4]dioxan-2-yl-7-hydroxy-9,9a-dihy...)
Affinity DataIC50:  1.19E+4nMAssay Description:Inhibition of TNFalpha expression in U937 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50162637(1,3-Diamino-6-[1,4]dioxan-2-yl-7-hydroxy-9,9a-dihy...)
Affinity DataIC50:  620nMAssay Description:Concentration of 50% inhibition by compound towards mitogen activated protein kinase -activated protein kinase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed