BDBM50163634 1-((1R,2S)-2-(((S)-3-(4-fluorobenzyl)piperidin-1-yl)methyl)cyclohexyl)-3-(3-(1-methyl-1H-tetrazol-5-yl)phenyl)urea::1-{(1R,2S)-2-[(S)-3-(4-Fluoro-benzyl)-piperidin-1-ylmethyl]-cyclohexyl}-3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea::CHEMBL363840

SMILES Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1

InChI Key InChIKey=HEXTXRMVMKIBQR-RZPFDVGOSA-N

Data  22 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50163634   

TargetCytochrome P450 2D6(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50163634(1-((1R,2S)-2-(((S)-3-(4-fluorobenzyl)piperidin-1-y...)
Affinity DataIC50:  200nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50163634(1-((1R,2S)-2-(((S)-3-(4-fluorobenzyl)piperidin-1-y...)
Affinity DataIC50:  0.0100nMAssay Description:Antagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophilMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50163634(1-((1R,2S)-2-(((S)-3-(4-fluorobenzyl)piperidin-1-y...)
Affinity DataIC50:  0.0100nMAssay Description:Antagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil at 30 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50163634(1-((1R,2S)-2-(((S)-3-(4-fluorobenzyl)piperidin-1-y...)
Affinity DataIC50:  1nMAssay Description:Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50163634(1-((1R,2S)-2-(((S)-3-(4-fluorobenzyl)piperidin-1-y...)
Affinity DataIC50:  2nMAssay Description:Binding affinity to CCR3 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50163634(1-((1R,2S)-2-(((S)-3-(4-fluorobenzyl)piperidin-1-y...)
Affinity DataIC50:  30nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50163634(1-((1R,2S)-2-(((S)-3-(4-fluorobenzyl)piperidin-1-y...)
Affinity DataIC50:  1nMAssay Description:Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50163634(1-((1R,2S)-2-(((S)-3-(4-fluorobenzyl)piperidin-1-y...)
Affinity DataIC50:  0.0100nMAssay Description:Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed