BDBM50163748 (E)-3,5-Bis[beta-(4-Hydroxy-3-methoxyphenyl)-ethenyl]-1H-pyrazole::4,4'-2,2'-(1H-pyrazole-3,5-diyl)bis(ethene-2,1-diyl)bis(2-methoxyphenol)::4,40-(1E,10E)-2,20-(1-H-Pyrazole-3,5-diyl)bis(ethene-2,1-diyl)bis(2-methoxyphenol)::4-((E)-2-{3-[(E)-2-(4-hydroxy-3-methoxyphenyl)vinyl]-1H-pyrazol-5-yl}vinyl)-2-methoxyphenol::4-(2-(5-(4-hydroxy-3-methoxystyryl)-1H-pyrazol-3-yl)vinyl)-2-methoxyphenol::CHEMBL180239
SMILES COc1cc(\C=C\c2cc(\C=C\c3ccc(O)c(OC)c3)[nH]n2)ccc1O
InChI Key InChIKey=LKLASFRCXLTNMY-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 21 hits for monomerid = 50163748
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Rajiv Gandhi Centre For Biotechnology
Curated by ChEMBL
Rajiv Gandhi Centre For Biotechnology
Curated by ChEMBL
Affinity DataIC50: 1.49E+3nMAssay Description:Inhibition of alphaCaMK2 using GST-NR2A as substrate incubated for 1 min prior to substrate addition measured after 1 minMore data for this Ligand-Target Pair
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of tau (unknown origin) transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibition of amyloid beta 42 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9.70E+3nMAssay Description:Inhibition of amyloid beta 40 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
Affinity DataIC50: 476nMAssay Description:Inhibition of amyloid beta 42 transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.27E+5nMAssay Description:Inhibition of wild type alpha-synuclein aggregation (unknown origin) expressed in Escherichia coli BL21 cells incubated for 30 days by thioflavin T b...More data for this Ligand-Target Pair
Affinity DataIC50: 1.94E+4nMAssay Description:Reduction of MMP9 activity in TNF-alpha/IL1-beta-stimulated human Caco-2 cells treated 1 hr before stimulation by zymographyMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
National Institute of Pharmaceutical Education and Research (NIPER)
Curated by ChEMBL
National Institute of Pharmaceutical Education and Research (NIPER)
Curated by ChEMBL
Affinity DataIC50: 9.70E+3nMAssay Description:Anti-oxidant activity in DPPH radicak scavenging assay; n=3-4More data for this Ligand-Target Pair
Affinity DataEC50: 7.25E+3nMAssay Description:Binding affinity to PKCtheta C1B subdomain after 1 hr by fluorescence quenching analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 1.88E+4nMAssay Description:Binding affinity to PKCepsilon C1B subdomain after 1 hr by fluorescence quenching analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 1.50E+4nMAssay Description:Binding affinity to PKCdelta C1B subdomain after 1 hr by fluorescence quenching analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of 12-LO in human neutrophilsMore data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Rajiv Gandhi Centre For Biotechnology
Curated by ChEMBL
Rajiv Gandhi Centre For Biotechnology
Curated by ChEMBL
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of autophosphorylated alphaCaMK2 using GST-NR2A as substrate incubated for 1 min prior to substrate addition measured after 1 minMore data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Rajiv Gandhi Centre For Biotechnology
Curated by ChEMBL
Rajiv Gandhi Centre For Biotechnology
Curated by ChEMBL
Affinity DataIC50: 290nMAssay Description:Inhibition of autophosphorylated alphaCaMK2 using GST-NR2A as substrate incubated for 1 min prior to substrate addition measured after 1 min in prese...More data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Rajiv Gandhi Centre For Biotechnology
Curated by ChEMBL
Rajiv Gandhi Centre For Biotechnology
Curated by ChEMBL
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of alphaCaMK2 autophosphorylation at Thr286 using [gamma32P]ATP incubated for 30 secs prior to ATP addition measured after 30 secsMore data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of human recombinant 5-LO expressed in Escherichia coli Bl21 (DE3) using arachidonic acid as substrate preincubated for 10 mins measured a...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of 5-LO-mediated 5,12-DiHETE formation in LPS-stimulated human monocytes preincubated for 15 mins before arachidonic acid substrate additi...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of 5-LO-mediated 5-HETE formation in LPS-stimulated human monocytes preincubated for 15 mins before arachidonic acid substrate addition me...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of 5-LO-mediated LTB4 formation in LPS-stimulated human monocytes preincubated for 15 mins before arachidonic acid substrate addition meas...More data for this Ligand-Target Pair
Affinity DataIC50: 700nMAssay Description:Inhibition of 5-LO in human neutrophils using arachidonic acid as substrate preincubated for 15 mins measured after 10 mins by HPLC analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.62E+4nMAssay Description:Inhibition of STAT3 transcriptional activity in human HaCaT cells after 6 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair