BDBM50164696 CHEMBL195641::N*4*-[4-(3H-Benzoimidazol-5-ylamino)-5-trifluoromethyl-pyrimidin-2-yl]-benzene-1,2,4-triamine derivative

SMILES FC(F)(F)c1cnc(Nc2ccc(NC#N)c(NC#N)c2)nc1Nc1ccc2nc[nH]c2c1

InChI Key InChIKey=QXAJGNKSKVWFIR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50164696   

TargetMitogen-activated protein kinase 3(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50164696(CHEMBL195641 | N*4*-[4-(3H-Benzoimidazol-5-ylamino...)
Affinity DataIC50:  300nMAssay Description:Inhibitory concentration against Extracellular signal-regulated kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50164696(CHEMBL195641 | N*4*-[4-(3H-Benzoimidazol-5-ylamino...)
Affinity DataIC50:  260nMAssay Description:Inhibitory concentration against Cyclin dependent kinase 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50164696(CHEMBL195641 | N*4*-[4-(3H-Benzoimidazol-5-ylamino...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration against Cyclin dependent kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50164696(CHEMBL195641 | N*4*-[4-(3H-Benzoimidazol-5-ylamino...)
Affinity DataIC50:  260nMAssay Description:Inhibitory concentration against Cyclin dependent kinase 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed