BDBM50166852 CHEMBL3797717

SMILES CC(C)CS(=O)(=O)n1ccc2c(cc(nc12)N1CCN(C)CC1)-c1ccc(cc1)C(F)(F)F

InChI Key InChIKey=RYBRXOLQVVUVSC-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50166852   

Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Selvita

Curated by ChEMBL
LigandPNGBDBM50166852(CHEMBL3797717)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]LSD from human 5HT6 receptor in HEK293 cell membrane incubated for 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Selvita

Curated by ChEMBL
LigandPNGBDBM50166852(CHEMBL3797717)
Affinity DataKi:  367nMAssay Description:Displacement of [3H]NMSP from human dopamine D2S receptor expressed in CHO cell membrane incubated for 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Selvita

Curated by ChEMBL
LigandPNGBDBM50166852(CHEMBL3797717)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of human recombinant CYP2D6 using AMMC as substrate incubated for 45 mins by fluorescence analysis in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Selvita

Curated by ChEMBL
LigandPNGBDBM50166852(CHEMBL3797717)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of human ERG1 expressed in CHO cells by whole cell patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Selvita

Curated by ChEMBL
LigandPNGBDBM50166852(CHEMBL3797717)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human recombinant CYP3A4 using 7-benzyloxy-trifluoromethylcoumarin as substrate incubated for 30 mins by fluorescence analysis in prese...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed