BDBM50168294 CHEMBL3805592::US9765060, Compound 104

SMILES C[C@H](Nc1nc(Cl)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1

InChI Key InChIKey=CIYIAGNLSXJOJR-NSHDSACASA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50168294   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM50168294(CHEMBL3805592 | US9765060, Compound 104)
Affinity DataIC50:  4nMAssay Description:TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIP3 for binding to the GRP-1 plecks...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50168294(CHEMBL3805592 | US9765060, Compound 104)
Affinity DataIC50:  4.30nMAssay Description:Inhibition human full length PI3Kdelta catalytic subunit/p85alpha assessed as formation of PIP3 after 30 mins by europium labeled GRP-based TR-FRET a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed