BDBM50169493 (S)-3,3-dimethyl-1-(4-(4-(trifluoromethyl)phenyl)-1H-imidazol-1-yl)butan-2-yl(S)-1-(1H-pyrazol-5-ylamino)-1,2-dioxoheptan-3-ylcarbamate::CHEMBL191584::[(S)-1-(2H-Pyrazol-3-ylaminooxalyl)-pentyl]-carbamic acid (S)-2,2-dimethyl-1-[4-(4-trifluoromethyl-phenyl)-imidazol-1-ylmethyl]-propyl ester

SMILES CCCC[C@H](NC(=O)O[C@H](Cn1cnc(c1)-c1ccc(cc1)C(F)(F)F)C(C)(C)C)C(=O)C(=O)Nc1ccn[nH]1

InChI Key InChIKey=IBVYZTXPOAZNHM-PZJWPPBQSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50169493   

TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50169493((S)-3,3-dimethyl-1-(4-(4-(trifluoromethyl)phenyl)-...)
Affinity DataIC50:  26nMAssay Description:Inhibition of 10 lM Cbz-Phe-Arg-AMC binding to human cathepsin K in fluorescence assay with 100 mM NaOAcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50169493((S)-3,3-dimethyl-1-(4-(4-(trifluoromethyl)phenyl)-...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of 5 lM Cbz-Phe-Arg-AMC bindign to human cathepsin L activity in fluorescence assay with 100 mM NaOAcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50169493((S)-3,3-dimethyl-1-(4-(4-(trifluoromethyl)phenyl)-...)
Affinity DataIC50:  0.0251nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50169493((S)-3,3-dimethyl-1-(4-(4-(trifluoromethyl)phenyl)-...)
Affinity DataIC50:  130nMAssay Description:Inhibition of 2 lM Cbz-Phe-Arg-AMC binding to human cathepsin V activity in fluorescence assay with 100 mM NaOAcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50169493((S)-3,3-dimethyl-1-(4-(4-(trifluoromethyl)phenyl)-...)
Affinity DataIC50:  2.70E+4nMAssay Description:Inhibition of 10 lM Cbz-Phe-Arg-AMC binding to human cathepsin B activity in fluorescence assay with 100 mM NaOAcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50169493((S)-3,3-dimethyl-1-(4-(4-(trifluoromethyl)phenyl)-...)
Affinity DataIC50:  160nMAssay Description:Inhibition of 10 lM Cbz-Val-Val-Arg-AMC binding to human cathepsin S in fluorescence assay with 100 mM NaOAcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed