BDBM50170831 CHEMBL188343::N*6*-Cyclohexyl-N*2*-(4-morpholin-4-yl-phenyl)-9H-purine-2,6-diamine::N6-cyclohexyl-N2-(4-morpholinophenyl)-9H-purine-2,6-diamine::N~6~-cyclohexyl-N~2~-(4-morpholin-4-ylphenyl)-9H-purine-2,6-diamine

SMILES C1CCC(CC1)Nc1nc(Nc2ccc(cc2)N2CCOCC2)nc2nc[nH]c12

InChI Key InChIKey=ZFLJHSQHILSNCM-UHFFFAOYSA-N

Data  3 KI  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50170831   

TargetAdenosine receptor A3(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50170831(CHEMBL188343 | N*6*-Cyclohexyl-N*2*-(4-morpholin-4...)
Affinity DataKi:  660nMAssay Description:Inhibition of [125I]- AB-MECA binding to human adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50170831(CHEMBL188343 | N*6*-Cyclohexyl-N*2*-(4-morpholin-4...)
Affinity DataKi: >1.00E+4nMAssay Description:Percent inhibition of [3H]-DPCPX binding to human adenosine A1 receptor expressed in CHO cells at 10 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50170831(CHEMBL188343 | N*6*-Cyclohexyl-N*2*-(4-morpholin-4...)
Affinity DataKi: >1.00E+4nMAssay Description:Percent inhibition of [3H]ZM241,385 binding to human adenosine A2a receptor expressed in CHO cells at 10 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Myrexis

Curated by ChEMBL
LigandPNGBDBM50170831(CHEMBL188343 | N*6*-Cyclohexyl-N*2*-(4-morpholin-4...)
Affinity DataIC50:  4nMAssay Description:Inhibition of Mps1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Myrexis

Curated by ChEMBL
LigandPNGBDBM50170831(CHEMBL188343 | N*6*-Cyclohexyl-N*2*-(4-morpholin-4...)
Affinity DataIC50:  110nMAssay Description:Inhibition of Aur AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Myrexis

Curated by ChEMBL
LigandPNGBDBM50170831(CHEMBL188343 | N*6*-Cyclohexyl-N*2*-(4-morpholin-4...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of PLK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Myrexis

Curated by ChEMBL
LigandPNGBDBM50170831(CHEMBL188343 | N*6*-Cyclohexyl-N*2*-(4-morpholin-4...)
Affinity DataIC50:  400nMAssay Description:Inhibition of recombinant full-length His-tagged human Aurora A expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50170831(CHEMBL188343 | N*6*-Cyclohexyl-N*2*-(4-morpholin-4...)
Affinity DataIC50:  500nMAssay Description:Inhibition of recombinant full-length His-tagged human Aurora B expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50170831(CHEMBL188343 | N*6*-Cyclohexyl-N*2*-(4-morpholin-4...)
Affinity DataIC50:  400nMAssay Description:Inhibition of recombinant full-length His-tagged human Aurora C expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Myrexis

Curated by ChEMBL
LigandPNGBDBM50170831(CHEMBL188343 | N*6*-Cyclohexyl-N*2*-(4-morpholin-4...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of human TTK-mediated MAD1/MAD2 complex phosphorylation after 1 hr by scintillation counting analysis in presence of gamma-[32P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50170831(CHEMBL188343 | N*6*-Cyclohexyl-N*2*-(4-morpholin-4...)
Affinity DataIC50:  75nMAssay Description:Inhibition of Aur BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Mus musculus)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50170831(CHEMBL188343 | N*6*-Cyclohexyl-N*2*-(4-morpholin-4...)
Affinity DataIC50:  8nMAssay Description:Inhibition of MEK1 in mouse C2C12 by ERK2 phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed