BDBM50171261 3-(2-Dimethylamino-ethyl)-1-methyl-1H-indol-4-ol::CHEMBL197664

SMILES CN(C)CCc1cn(C)c2cccc(O)c12

InChI Key InChIKey=MZZRFEIDRWKTKJ-UHFFFAOYSA-N

Data  6 KI  3 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50171261   

Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50171261(3-(2-Dimethylamino-ethyl)-1-methyl-1H-indol-4-ol |...)
Affinity DataKi:  7nMAssay Description:Inhibition constant against human 5-hydroxytryptamine 2C receptor [INI isoforms] using [3H]-mesulergine as radioligand with the compound (10 uM) diss...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50171261(3-(2-Dimethylamino-ethyl)-1-methyl-1H-indol-4-ol |...)
Affinity DataKi:  33nMAssay Description:Inhibition constant against human 5-hydroxytryptamine 2C receptor [VGI isoforms] using [3H]-mesulergine as radioligand with the compound (10 uM) diss...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50171261(3-(2-Dimethylamino-ethyl)-1-methyl-1H-indol-4-ol |...)
Affinity DataKi:  38nMAssay Description:Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]-LSD as radioligand with the compound (10 uM) dissolved in DMSOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
Organix

Curated by ChEMBL
LigandPNGBDBM50171261(3-(2-Dimethylamino-ethyl)-1-methyl-1H-indol-4-ol |...)
Affinity DataKi:  48nMAssay Description:Inhibition constant against rat 5-hydroxytryptamine 2C receptor using [3H]-mesulergine as radioligand with the compound (10 uM) dissolved in DMSOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Organix

Curated by ChEMBL
LigandPNGBDBM50171261(3-(2-Dimethylamino-ethyl)-1-methyl-1H-indol-4-ol |...)
Affinity DataKi:  590nMAssay Description:Inhibition constant against rat 5-hydroxytryptamine 2A receptor using [3H]-ketanserin as radioligand with the compound (10 uM) dissolved in DMSOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50171261(3-(2-Dimethylamino-ethyl)-1-methyl-1H-indol-4-ol |...)
Affinity DataKi:  900nMAssay Description:Inhibition constant against human 5-hydroxytryptamine 2A receptor using [3H]-ketanserin as radioligand with the compound (10 uM) dissolved in DMSOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50171261(3-(2-Dimethylamino-ethyl)-1-methyl-1H-indol-4-ol |...)
Affinity DataIC50:  32nMAssay Description:Modulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50171261(3-(2-Dimethylamino-ethyl)-1-methyl-1H-indol-4-ol |...)
Affinity DataIC50:  86nMAssay Description:Modulation of human 5HT2A expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50171261(3-(2-Dimethylamino-ethyl)-1-methyl-1H-indol-4-ol |...)
Affinity DataIC50:  9.5nMAssay Description:Modulation of human 5HT2C expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50171261(3-(2-Dimethylamino-ethyl)-1-methyl-1H-indol-4-ol |...)
Affinity DataEC50:  633nMAssay Description:Effective concentration required for accumulation of [3H]-inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50171261(3-(2-Dimethylamino-ethyl)-1-methyl-1H-indol-4-ol |...)
Affinity DataEC50:  12nMAssay Description:Effective concentration required for accumulation of [3H]-inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2C receptor determi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed