BDBM50172414 2-(2,4-Dichloro-phenoxy)-N-[2-(2-dimethylamino-ethoxy)-4-methyl-quinolin-6-yl]-acetamide::CHEMBL194837

SMILES CN(C)CCOc1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1

InChI Key InChIKey=GKDBTHSYQZTDAJ-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50172414   

TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50172414(2-(2,4-Dichloro-phenoxy)-N-[2-(2-dimethylamino-eth...)
Affinity DataIC50:  1.70nMAssay Description:Inhibitory concentration against muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 2(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50172414(2-(2,4-Dichloro-phenoxy)-N-[2-(2-dimethylamino-eth...)
Affinity DataIC50:  8.70nMAssay Description:Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50172414(2-(2,4-Dichloro-phenoxy)-N-[2-(2-dimethylamino-eth...)
Affinity DataIC50:  0.200nMAssay Description:Inhibitory concentration against 5-hydroxytryptamine 1B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50172414(2-(2,4-Dichloro-phenoxy)-N-[2-(2-dimethylamino-eth...)
Affinity DataIC50:  1.48E+3nMAssay Description:Inhibitory concentration against 10 nM MCH-induced IP3 accumulation in CHO-K1 cells expressing human MCH1R after incubation with [3H]-myo-inositolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50172414(2-(2,4-Dichloro-phenoxy)-N-[2-(2-dimethylamino-eth...)
Affinity DataIC50:  85nMAssay Description:Displacement of 15 pM [125I]-MCH from human MCH1R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50172414(2-(2,4-Dichloro-phenoxy)-N-[2-(2-dimethylamino-eth...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibitory concentration against human 5-hydroxytryptamine 2C receptor expressed in CHO-K1 cells using [3H]-mesulergineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50172414(2-(2,4-Dichloro-phenoxy)-N-[2-(2-dimethylamino-eth...)
Affinity DataIC50:  1.30nMAssay Description:Inhibitory concentration against dopamine receptor D3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50172414(2-(2,4-Dichloro-phenoxy)-N-[2-(2-dimethylamino-eth...)
Affinity DataIC50:  3.5nMAssay Description:Inhibitory concentration against histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50172414(2-(2,4-Dichloro-phenoxy)-N-[2-(2-dimethylamino-eth...)
Affinity DataIC50: >10nMAssay Description:Inhibitory concentration against dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50172414(2-(2,4-Dichloro-phenoxy)-N-[2-(2-dimethylamino-eth...)
Affinity DataIC50:  7.5nMAssay Description:Inhibitory concentration against dopamine receptor D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50172414(2-(2,4-Dichloro-phenoxy)-N-[2-(2-dimethylamino-eth...)
Affinity DataIC50:  0.610nMAssay Description:Inhibitory concentration against 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50172414(2-(2,4-Dichloro-phenoxy)-N-[2-(2-dimethylamino-eth...)
Affinity DataIC50:  4.5nMAssay Description:Inhibitory concentration against muscarinic acetylcholine receptor M2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50172414(2-(2,4-Dichloro-phenoxy)-N-[2-(2-dimethylamino-eth...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibitory concentration against human 5-hydroxytryptamine 2C receptor expressed in CHO-K1 cells using [3H]-mesulergineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50172414(2-(2,4-Dichloro-phenoxy)-N-[2-(2-dimethylamino-eth...)
Affinity DataIC50:  180nMAssay Description:Displacement of 150p M [125I]-MCH from human MCH1R expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50172414(2-(2,4-Dichloro-phenoxy)-N-[2-(2-dimethylamino-eth...)
Affinity DataIC50:  0.870nMAssay Description:Inhibitory concentration against histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed