BDBM50174527 (S)-2-Amino-4-(hydroxy-methyl-phosphinoyl)-butyric acid; hydrochloride::CHEMBL145114::CHEMBL535153

SMILES CP(O)(=O)CC[C@H](N)C(O)=O

InChI Key InChIKey=IAJOBQBIJHVGMQ-BYPYZUCNSA-N

Data  1 KI  1 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50174527   

TargetGlutamine synthetase(Escherichia coli (strain K12))
Wroclaw University Of Technology

Curated by ChEMBL
LigandPNGBDBM50174527((S)-2-Amino-4-(hydroxy-methyl-phosphinoyl)-butyric...)
Affinity DataKi:  600nMAssay Description:Binding affinity towards glutamine synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 7(Rattus norvegicus (Rat))
Université

Curated by ChEMBL
LigandPNGBDBM50174527((S)-2-Amino-4-(hydroxy-methyl-phosphinoyl)-butyric...)
Affinity DataEC50: >5.00E+5nMAssay Description:Agonist activity at rat mGluR7 receptor expressed HEK293 cells assessed as effect on inositol phosphate productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Rattus norvegicus (Rat))
Université

Curated by ChEMBL
LigandPNGBDBM50174527((S)-2-Amino-4-(hydroxy-methyl-phosphinoyl)-butyric...)
Affinity DataEC50:  4.12E+5nMAssay Description:Agonist activity at rat mGluR8 receptor expressed HEK293 cells assessed as effect on inositol phosphate productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamine synthetase(Escherichia coli (strain K12))
Wroclaw University Of Technology

Curated by ChEMBL
LigandPNGBDBM50174527((S)-2-Amino-4-(hydroxy-methyl-phosphinoyl)-butyric...)
Affinity DataIC50:  1.20E+3nMpH: 7.4Assay Description:Inhibitory concentration against glutamine synthetase incubated at 37 degree C for 20 minutes in pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Université

Curated by ChEMBL
LigandPNGBDBM50174527((S)-2-Amino-4-(hydroxy-methyl-phosphinoyl)-butyric...)
Affinity DataEC50: >5.00E+5nMAssay Description:Agonist activity at rat mGluR6 receptor expressed HEK293 cells assessed as effect on inositol phosphate productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
Université

Curated by ChEMBL
LigandPNGBDBM50174527((S)-2-Amino-4-(hydroxy-methyl-phosphinoyl)-butyric...)
Affinity DataEC50:  1.10E+6nMAssay Description:Agonist activity at rat mGluR4 receptor expressed HEK293 cells assessed as effect on inositol phosphate productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed