BDBM50174837 4'-(p-toluenesulfonamide)-3,4-dihydroxy chalcone::CHEMBL199829::Sulfonamide chalcone, 5

SMILES Cc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)C(=O)\C=C\c1ccc(O)c(O)c1

InChI Key InChIKey=XCEAUELSIXURQB-UUILKARUSA-N

Data  1 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50174837   

TargetTrans-sialidase(Trypanosoma cruzi)
University of British Columbia

LigandPNGBDBM50174837(4'-(p-toluenesulfonamide)-3,4-dihydroxy chalcone |...)
Affinity DataKi:  4.60E+3nM ΔG°:  -7.52kcal/mole IC50:  900nMpH: 7.6 T: 2°CAssay Description:Inhibition assay using trans-sialidase, a membrane-associated protein.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-mannosidase(Canavalia ensiformis)
Shiv Nadar University

Curated by ChEMBL
LigandPNGBDBM50174837(4'-(p-toluenesulfonamide)-3,4-dihydroxy chalcone |...)
Affinity DataIC50:  1.05E+5nMAssay Description:Inhibition of jack bean alpha-mannosidase using PNPG as substrate incubated for 10 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50174837(4'-(p-toluenesulfonamide)-3,4-dihydroxy chalcone |...)
Affinity DataIC50:  900nMAssay Description:Inhibition of Trypanosoma cruzi trans-sialidase using CF3MuSA as substrate by UV/visible spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue alpha-L-fucosidase(Bos taurus)
Shiv Nadar University

Curated by ChEMBL
LigandPNGBDBM50174837(4'-(p-toluenesulfonamide)-3,4-dihydroxy chalcone |...)
Affinity DataIC50:  9.10E+4nMAssay Description:Inhibition of bovine kidney alpha-fucosidase using PNPG as substrate incubated for 10 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-amylase(Bacillus licheniformis)
Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50174837(4'-(p-toluenesulfonamide)-3,4-dihydroxy chalcone |...)
Affinity DataIC50:  1.94E+5nMAssay Description:Inhibitory activity against Bacillus licheniformis alpha amylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-amylase(Hordeum vulgare)
Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50174837(4'-(p-toluenesulfonamide)-3,4-dihydroxy chalcone |...)
Affinity DataIC50:  6.50E+4nMAssay Description:Inhibitory activity against barley beta amylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed