BDBM50174929 CHEMBL369899::N-(2-chloro-5-methoxypyridin-3-yl)-7-(3-morpholinopropoxy)-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine

SMILES COc1cnc(Cl)c(Nc2ncnc3cc(OCCCN4CCOCC4)cc(OC4CCOCC4)c23)c1

InChI Key InChIKey=OUHMRQBQOUEGJV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50174929   

TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50174929(CHEMBL369899 | N-(2-chloro-5-methoxypyridin-3-yl)-...)
Affinity DataIC50:  140nMAssay Description:Inhibition of Src-transfected 3T3 cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50174929(CHEMBL369899 | N-(2-chloro-5-methoxypyridin-3-yl)-...)
Affinity DataIC50:  7nMAssay Description:Inhibitory activity against c-Src kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50174929(CHEMBL369899 | N-(2-chloro-5-methoxypyridin-3-yl)-...)
Affinity DataIC50:  30nMAssay Description:Inhibitory activity against KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed