BDBM50176320 CHEMBL381447::N-(2-(4-(4-chloro-3-hydroxyphenyl)-5-(pyridin-4-yl)-1H-imidazol-2-yl)-2-methylpropyl)methanesulfonamide

SMILES CC(C)(CNS(C)(=O)=O)c1nc(c([nH]1)-c1ccc(Cl)c(O)c1)-c1ccncc1

InChI Key InChIKey=CMKGLLDJHXJPIV-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50176320   

TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50176320(CHEMBL381447 | N-(2-(4-(4-chloro-3-hydroxyphenyl)-...)
Affinity DataIC50:  14nMAssay Description:Inhibition bRaf kinase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50176320(CHEMBL381447 | N-(2-(4-(4-chloro-3-hydroxyphenyl)-...)
Affinity DataKd:  10nMAssay Description:Binding affinity at bRaf kinase in fluorescent ligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed