BDBM50177855 CHEMBL3814482
SMILES CN1CCC(CC1)n1cc(cn1)-c1cnc(N)c(n1)-c1nc2ccccc2n1Cc1cccc(NC(=O)C=C)c1
InChI Key InChIKey=USSKRCQDDVHMIX-UHFFFAOYSA-N
Data 3 EC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 50177855
Affinity DataEC50: >2.50E+4nMAssay Description:Inhibition of wild-type EGFR autophosphorylation in human LoVo cells incubated for 2 hrs followed by EGF-stiumlation for 10 mins by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 360nMAssay Description:Inhibition of EGFR T790M/L858R double mutant autophosphorylation in human NCI-H1975 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 280nMAssay Description:Inhibition of EGFR exon19 deletion activating mutant autophosphorylation in human PC9 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair