BDBM50178143 CHEMBL3813817
SMILES Nc1ncc(nc1-c1nc2ccccc2n1-c1cccc(NC(=O)C=C)c1)-c1cnn(CCO)c1
InChI Key InChIKey=KCMPEKMMIZIXJG-UHFFFAOYSA-N
Data 3 EC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 50178143
Affinity DataEC50: 8nMAssay Description:Inhibition of EGFR exon19 deletion activating mutant autophosphorylation in human PC9 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 2.25E+3nMAssay Description:Inhibition of wild-type EGFR autophosphorylation in human LoVo cells incubated for 2 hrs followed by EGF-stiumlation for 10 mins by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 12nMAssay Description:Inhibition of EGFR T790M/L858R double mutant autophosphorylation in human NCI-H1975 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair