BDBM50178975 4,6-dichloro-5-(4-hydroxy-3-isopropylphenoxy)-1H-indole-2-carboxylic acid::CHEMBL203777

SMILES CC(C)c1cc(Oc2c(Cl)cc3[nH]c(cc3c2Cl)C(O)=O)ccc1O

InChI Key InChIKey=FWMUQGROYMTIHF-UHFFFAOYSA-N

Data  1 KI  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50178975   

TargetThyroid hormone receptor beta(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50178975(4,6-dichloro-5-(4-hydroxy-3-isopropylphenoxy)-1H-i...)
Affinity DataKi:  0.0600nMAssay Description:Binding affinity to TRbeta1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Karo Bio

Curated by ChEMBL
LigandPNGBDBM50178975(4,6-dichloro-5-(4-hydroxy-3-isopropylphenoxy)-1H-i...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human TRalpha1 by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Karo Bio

Curated by ChEMBL
LigandPNGBDBM50178975(4,6-dichloro-5-(4-hydroxy-3-isopropylphenoxy)-1H-i...)
Affinity DataEC50:  10nMAssay Description:Efficacy against TRAF-alpha-1 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50178975(4,6-dichloro-5-(4-hydroxy-3-isopropylphenoxy)-1H-i...)
Affinity DataIC50:  0.0603nMAssay Description:Inhibition of thyroid hormone receptor betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Karo Bio

Curated by ChEMBL
LigandPNGBDBM50178975(4,6-dichloro-5-(4-hydroxy-3-isopropylphenoxy)-1H-i...)
Affinity DataIC50:  1.41nMAssay Description:Inhibition of thyroid hormone receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50178975(4,6-dichloro-5-(4-hydroxy-3-isopropylphenoxy)-1H-i...)
Affinity DataIC50:  0.0600nMAssay Description:Inhibition of human TRbeta1 by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50178975(4,6-dichloro-5-(4-hydroxy-3-isopropylphenoxy)-1H-i...)
Affinity DataEC50:  4.70nMAssay Description:Efficacy against TRAF-beta-1 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed