BDBM50179073 (4R,9aR)-6-Cyclopropylmethoxymethyl-4-methyl-1,2,3,4,9,9a-hexahydro-2,4a,5-triaza-fluorene::CHEMBL203013

SMILES C[C@@H]1CNC[C@H]2Cc3ccc(COCC4CC4)nc3N12

InChI Key InChIKey=LJRLAJVWAFFRLV-IAQYHMDHSA-N

Data  17 KI  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50179073   

Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179073((4R,9aR)-6-Cyclopropylmethoxymethyl-4-methyl-1,2,3...)
Affinity DataKi:  3.60nMAssay Description:Displacement of [3H]-5HT from human recombinant 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179073((4R,9aR)-6-Cyclopropylmethoxymethyl-4-methyl-1,2,3...)
Affinity DataKi:  4nMAssay Description:Binding affinity to 5-HT2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179073((4R,9aR)-6-Cyclopropylmethoxymethyl-4-methyl-1,2,3...)
Affinity DataKi:  74nMAssay Description:Displacement of [125I]DOI from human recombinant 5HT2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179073((4R,9aR)-6-Cyclopropylmethoxymethyl-4-methyl-1,2,3...)
Affinity DataKi:  174nMAssay Description:Displacement of [3H]-5HT from human recombinant 5HT2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179073((4R,9aR)-6-Cyclopropylmethoxymethyl-4-methyl-1,2,3...)
Affinity DataKi: >360nMAssay Description:Binding affinity to 5HT1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179073((4R,9aR)-6-Cyclopropylmethoxymethyl-4-methyl-1,2,3...)
Affinity DataKi: >720nMAssay Description:Binding affinity to 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179073((4R,9aR)-6-Cyclopropylmethoxymethyl-4-methyl-1,2,3...)
Affinity DataKi: >720nMAssay Description:Binding affinity to 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179073((4R,9aR)-6-Cyclopropylmethoxymethyl-4-methyl-1,2,3...)
Affinity DataKi: >720nMAssay Description:Binding affinity to D4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179073((4R,9aR)-6-Cyclopropylmethoxymethyl-4-methyl-1,2,3...)
Affinity DataKi: >720nMAssay Description:Binding affinity to 5HT1B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 5A(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179073((4R,9aR)-6-Cyclopropylmethoxymethyl-4-methyl-1,2,3...)
Affinity DataKi: >720nMAssay Description:Binding affinity to 5HT5A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179073((4R,9aR)-6-Cyclopropylmethoxymethyl-4-methyl-1,2,3...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to NA transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179073((4R,9aR)-6-Cyclopropylmethoxymethyl-4-methyl-1,2,3...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to 5HT transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179073((4R,9aR)-6-Cyclopropylmethoxymethyl-4-methyl-1,2,3...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to mu type opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179073((4R,9aR)-6-Cyclopropylmethoxymethyl-4-methyl-1,2,3...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to beta1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179073((4R,9aR)-6-Cyclopropylmethoxymethyl-4-methyl-1,2,3...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to DA transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179073((4R,9aR)-6-Cyclopropylmethoxymethyl-4-methyl-1,2,3...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to 5HT7 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179073((4R,9aR)-6-Cyclopropylmethoxymethyl-4-methyl-1,2,3...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to 5HT3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179073((4R,9aR)-6-Cyclopropylmethoxymethyl-4-methyl-1,2,3...)
Affinity DataEC50:  15nMAssay Description:Efficacy against human recombinant 5HT2C receptor induced intracellular calcium mobilization in CHO cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179073((4R,9aR)-6-Cyclopropylmethoxymethyl-4-methyl-1,2,3...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of hERG potassium channel expressed in CHO cells by whole cell patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179073((4R,9aR)-6-Cyclopropylmethoxymethyl-4-methyl-1,2,3...)
Affinity DataEC50:  23nMAssay Description:Efficacy against human recombinant 5HT2B receptor induced intracellular calcium mobilization in CHO cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed