BDBM50179335 (5-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperazin-1-yl)-methanone::(5-chloro-1H-benzoimidazol-2-yl)(4-methylpiperazin-1-yl)methanone::CHEMBL185951

SMILES CN1CCN(CC1)C(=O)c1nc2ccc(Cl)cc2[nH]1

InChI Key InChIKey=MOIWSUQWIOVGRH-UHFFFAOYSA-N

Data  10 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50179335   

TargetHistamine H4 receptor(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50179335((5-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperaz...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50179335((5-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperaz...)
Affinity DataKi:  26nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50179335((5-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperaz...)
Affinity DataKi:  26nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50179335((5-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperaz...)
Affinity DataKi:  26nMAssay Description:Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50179335((5-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperaz...)
Affinity DataKi:  39.6nMAssay Description:Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50179335((5-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperaz...)
Affinity DataKi:  39.6nMAssay Description:Antagonist activity at human histamine H4 receptor by functional assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50179335((5-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperaz...)
Affinity DataKi:  47.7nMAssay Description:Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50179335((5-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperaz...)
Affinity DataKi:  47.7nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50179335((5-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperaz...)
Affinity DataKi:  1.41E+4nMAssay Description:Binding affinity to histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50179335((5-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperaz...)
Affinity DataKi:  2.00E+4nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed