BDBM50180684 4-OHT::Afimoxifene::TamoGel
SMILES CC\C(=C(/c1ccccc1)c1ccc(OCCN(C)C)cc1)c1ccc(O)cc1
InChI Key InChIKey=DODQJNMQWMSYGS-QPLCGJKRSA-N
Data 11 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 50180684
TargetAromatase(Homo sapiens (Human))
State University Of New York Upstate Medical University
Curated by ChEMBL
State University Of New York Upstate Medical University
Curated by ChEMBL
Affinity DataIC50: 5.30E+5nMAssay Description:Inhibition of human placental microsomal aromatase using testosterone as substrate assessed as formation of estradiol after 10 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.530nMAssay Description:Displacement of fluormone-labeled ES2 from recombinant full length human ERalpha ligand binding domain expressed in insect cells after 2 hrs by TR-FR...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Induction of selective estrogen receptor alpha degradation in human MCF7 cells harboring TK-ERE-Luc assessed as reduction in estradiol-induced transc...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Induction of selective estrogen receptor alpha degradation in human MCF7 cells harboring TK-ERE-Luc assessed as reduction in estradiol-induced GREB1 ...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Antagonist activity at ERalpha in human T47D-KBLuc cells assessed as inhibition of E2-induced transcriptional activity by luciferase reporter gene as...More data for this Ligand-Target Pair
Affinity DataIC50: >100nMAssay Description:Antagonist activity at progesterone receptor in human MCF7 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of LSD1 (unknown origin) incubated for 90 mins by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Antagonist activity at ERalpha (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3.60nMAssay Description:Antagonist activity at ERbeta (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >100nMAssay Description:Antagonist activity at ERalpha in human MCF7 cells assessed as downregulation of ERalphaMore data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Antagonist activity at luciferase-fused ERalpha in human HEK293 cells expressing eYFP assessed as reduction of E2-induced estrogenic activity after 2...More data for this Ligand-Target Pair