BDBM50181317 3-(1H-benzo[d]imidazol-2-yl)-4-hydroxyquinolin-2(1H)-one::CHEMBL377345

SMILES Oc1c(-c2nc3ccccc3[nH]2)c(=O)[nH]c2ccccc12

InChI Key InChIKey=YXCWBNCDJZEBKY-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50181317   

TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50181317(3-(1H-benzo[d]imidazol-2-yl)-4-hydroxyquinolin-2(1...)
Affinity DataIC50:  2.95E+3nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50181317(3-(1H-benzo[d]imidazol-2-yl)-4-hydroxyquinolin-2(1...)
Affinity DataIC50:  215nMAssay Description:Inhibitory activity against FGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Mus musculus)
Chiron

Curated by ChEMBL
LigandPNGBDBM50181317(3-(1H-benzo[d]imidazol-2-yl)-4-hydroxyquinolin-2(1...)
Affinity DataIC50:  114nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50181317(3-(1H-benzo[d]imidazol-2-yl)-4-hydroxyquinolin-2(1...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human recombinant PDGFRbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50181317(3-(1H-benzo[d]imidazol-2-yl)-4-hydroxyquinolin-2(1...)
Affinity DataIC50:  162nMAssay Description:Inhibitory activity against VEGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50181317(3-(1H-benzo[d]imidazol-2-yl)-4-hydroxyquinolin-2(1...)
Affinity DataIC50:  240nMAssay Description:Inhibition of human recombinant VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50181317(3-(1H-benzo[d]imidazol-2-yl)-4-hydroxyquinolin-2(1...)
Affinity DataIC50:  90nMAssay Description:Inhibition of human recombinant FGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Mus musculus (mouse))
Chiron

Curated by ChEMBL
LigandPNGBDBM50181317(3-(1H-benzo[d]imidazol-2-yl)-4-hydroxyquinolin-2(1...)
Affinity DataIC50:  395nMAssay Description:Inhibitory activity against PDGFRbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed