BDBM50181873 CHEMBL383229::N-[4-(4,4-dimethylpiperidin-1-yl)benzoyl]-3-nitro-4-(2-phenylsulfanylethylamino)benzenesulfonamide

SMILES CC1(C)CCN(CC1)c1ccc(cc1)C(=O)NS(=O)(=O)c1ccc(NCCSc2ccccc2)c(c1)[N+]([O-])=O

InChI Key InChIKey=TZOBOAHCWXVNEO-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50181873   

TargetBcl-2-like protein 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181873(CHEMBL383229 | N-[4-(4,4-dimethylpiperidin-1-yl)be...)
Affinity DataKi:  19nMAssay Description:Binding affinity to Bcl-XL by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181873(CHEMBL383229 | N-[4-(4,4-dimethylpiperidin-1-yl)be...)
Affinity DataKi:  192nMAssay Description:Binding affinity to Bcl2 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181873(CHEMBL383229 | N-[4-(4,4-dimethylpiperidin-1-yl)be...)
Affinity DataKi:  652nMAssay Description:Binding affinity to Bcl-XL in 1% human serum by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181873(CHEMBL383229 | N-[4-(4,4-dimethylpiperidin-1-yl)be...)
Affinity DataIC50:  79nMAssay Description:Inhibition of FITC-labeled Bak BH3 peptide binding to His6-tagged GST-fused Bcl-xL (unknown origin) expressed in Escherichia coli BL21 preincubated f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed