BDBM50181877 4-((R)-5-dimethylamino-1-phenylsulfanylmethylpentylamino)-N-[4-(4,4-dimethylpiperidin-1-yl)benzoyl]-3-nitrobenzenesulfonamide::CHEMBL370835

SMILES CN(C)CCCC[C@H](CSc1ccccc1)Nc1ccc(cc1[N+]([O-])=O)S(=O)(=O)NC(=O)c1ccc(cc1)N1CCC(C)(C)CC1

InChI Key InChIKey=DCUPDSTXISCXNY-HHHXNRCGSA-N

Data  3 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50181877   

TargetBcl-2-like protein 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181877(4-((R)-5-dimethylamino-1-phenylsulfanylmethylpenty...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity to Bcl-XL by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181877(4-((R)-5-dimethylamino-1-phenylsulfanylmethylpenty...)
Affinity DataKi:  73nMAssay Description:Binding affinity to Bcl2 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181877(4-((R)-5-dimethylamino-1-phenylsulfanylmethylpenty...)
Affinity DataKi:  174nMAssay Description:Binding affinity to Bcl-XL in 1% human serum by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181877(4-((R)-5-dimethylamino-1-phenylsulfanylmethylpenty...)
Affinity DataEC50:  1.08E+3nMAssay Description:Activity towards mouse FL5.12 cell line transfected with Bcl-XL in presence of gelatinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181877(4-((R)-5-dimethylamino-1-phenylsulfanylmethylpenty...)
Affinity DataEC50:  3.89E+3nMAssay Description:Activity towards mouse FL5.12 cell line transfected with Bcl-XL in presence of 3% fetal bovine serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed