BDBM50184872 4-(4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide::4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]-pyridin-2-yl}-N-(tetrahydro-2H-pyran-4-yl)benzamide::CHEMBL202887::GW-788388

SMILES O=C(NC1CCOCC1)c1ccc(cc1)-c1cc(ccn1)-c1c[nH]nc1-c1ccccn1

InChI Key InChIKey=SAGZIBJAQGBRQA-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50184872   

TargetTGF-beta receptor type-1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50184872(4-(4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-y...)
Affinity DataIC50:  18nMAssay Description:Inhibition of TGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransforming growth factor beta-1 proprotein(Homo sapiens (Human))
Monash University

Curated by ChEMBL
LigandPNGBDBM50184872(4-(4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-y...)
Affinity DataIC50:  446nMAssay Description:Inhibition of TGF-beta1 signaling in human HEK293 cells transfected with luciferase and FAST-2 gene expression vector A3-LUX after 16 hrs by lucifera...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50184872(4-(4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-y...)
Affinity DataIC50:  18nMAssay Description:Inhibition of TbetaR-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50184872(4-(4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-y...)
Affinity DataIC50:  18nMAssay Description:Displacement of rhodamine green fluorescently labeled ATP from recombinant GST-ALK5 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50184872(4-(4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-y...)
Affinity DataIC50:  7.28E+3nMAssay Description:Displacement of rhodamine green fluorescently labeled ATP from recombinant GST-p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed