BDBM50187253 ((3R)-1-(2-((3S)-2-hydroxy-5-oxotetrahydrofuran-3-ylamino)-2-oxoethyl)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)methyl 4-chloro-2-(trifluoromethyl)phenylcarbamate::((R)-1-(2-((3S)-2-hydroxy-5-oxo-tetrahydrofuran-3-ylamino)-2-oxoethyl)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)methyl 4-chloro-2-(trifluoromethyl)phenylcarbamate::(4-Chloro-2-trifluoromethylphenyl)-carbamic acid 1-[(2-hydroxy-5-oxo-tetrahydrofuran-3(S)-ylcarbamoyl)-methyl]-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3(R)-ylmethyl ester::CHEMBL378223

SMILES OC1OC(=O)C[C@@H]1NC(=O)CN1c2ccccc2C(=N[C@H](COC(=O)Nc2ccc(Cl)cc2C(F)(F)F)C1=O)c1ccccc1

InChI Key InChIKey=OERHYLYOHLZSHW-BBCCDPPWSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50187253   

TargetFalcipain 2(Plasmodium falciparum)
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50187253(((3R)-1-(2-((3S)-2-hydroxy-5-oxotetrahydrofuran-3-...)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibition of Plasmodium falciparum Falcipain-2 after 10 to 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFalcipain 2(Plasmodium falciparum)
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50187253(((3R)-1-(2-((3S)-2-hydroxy-5-oxotetrahydrofuran-3-...)
Affinity DataIC50:  8.68E+3nMAssay Description:Inhibition of Plasmodium falciparum recombinant FP2A fused with maltose binding proteinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFalcipain 2(Plasmodium falciparum)
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50187253(((3R)-1-(2-((3S)-2-hydroxy-5-oxotetrahydrofuran-3-...)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of Plasmodium falciparum recombinant falcipain-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFalcipain 2B(Plasmodium falciparum)
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50187253(((3R)-1-(2-((3S)-2-hydroxy-5-oxotetrahydrofuran-3-...)
Affinity DataIC50:  2.59E+4nMAssay Description:Inhibition of Plasmodium falciparum recombinant FP2B fused with maltose binding proteinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed