BDBM50187848 5-(2,3-dichlorophenylamino)-3-hydroxy-N-(1-hydroxypropan-2-yl)isothiazole-4-carboxamidine::5-2,3-dichlorophenylamino)-3-hydroxy-N-1-hydroxypropan-2-yl)isothiazole-4-carboximidamide::CHEMBL375609

SMILES CC(CO)NC(=N)c1c(Nc2cccc(Cl)c2Cl)s[nH]c1=O

InChI Key InChIKey=MTLKDHYIODZMOW-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50187848   

TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50187848(5-(2,3-dichlorophenylamino)-3-hydroxy-N-(1-hydroxy...)
Affinity DataIC50:  38nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50187848(5-(2,3-dichlorophenylamino)-3-hydroxy-N-(1-hydroxy...)
Affinity DataIC50:  38nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50187848(5-(2,3-dichlorophenylamino)-3-hydroxy-N-(1-hydroxy...)
Affinity DataEC50:  375nMAssay Description:Inhibitory activity against MEK-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed