BDBM50187995 1-(4-(4-aminoisothiazolo[5,4-d]pyrimidin-3-yl)phenyl)-3-m-tolylurea::CHEMBL376951

SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2nsc3ncnc(N)c23)c1

InChI Key InChIKey=FKFACVZGGDYEHZ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50187995   

TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50187995(1-(4-(4-aminoisothiazolo[5,4-d]pyrimidin-3-yl)phen...)
Affinity DataIC50:  4nMAssay Description:Inhibition of FLT4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50187995(1-(4-(4-aminoisothiazolo[5,4-d]pyrimidin-3-yl)phen...)
Affinity DataIC50:  1nMAssay Description:Inhibition of KDR by cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50187995(1-(4-(4-aminoisothiazolo[5,4-d]pyrimidin-3-yl)phen...)
Affinity DataIC50:  415nMAssay Description:Inhibition of TIE2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50187995(1-(4-(4-aminoisothiazolo[5,4-d]pyrimidin-3-yl)phen...)
Affinity DataIC50:  11nMAssay Description:Inhibition of CKITMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50187995(1-(4-(4-aminoisothiazolo[5,4-d]pyrimidin-3-yl)phen...)
Affinity DataIC50:  13nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50187995(1-(4-(4-aminoisothiazolo[5,4-d]pyrimidin-3-yl)phen...)
Affinity DataIC50:  79nMAssay Description:Inhibition of FLT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed