BDBM50187997 1-(4-(4-aminoisothiazolo[5,4-d]pyrimidin-3-yl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea::CHEMBL213504

SMILES Nc1ncnc2snc(-c3ccc(NC(=O)Nc4cccc(c4)C(F)(F)F)cc3)c12

InChI Key InChIKey=KIXJPVWFCZCXOL-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50187997   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50187997(1-(4-(4-aminoisothiazolo[5,4-d]pyrimidin-3-yl)phen...)
Affinity DataIC50:  5nMAssay Description:Inhibition of KDR by cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50187997(1-(4-(4-aminoisothiazolo[5,4-d]pyrimidin-3-yl)phen...)
Affinity DataIC50: <3nMAssay Description:Inhibition of FLT4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50187997(1-(4-(4-aminoisothiazolo[5,4-d]pyrimidin-3-yl)phen...)
Affinity DataIC50:  4nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50187997(1-(4-(4-aminoisothiazolo[5,4-d]pyrimidin-3-yl)phen...)
Affinity DataIC50:  28nMAssay Description:Inhibition of TIE2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50187997(1-(4-(4-aminoisothiazolo[5,4-d]pyrimidin-3-yl)phen...)
Affinity DataIC50:  39nMAssay Description:Inhibition of FLT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50187997(1-(4-(4-aminoisothiazolo[5,4-d]pyrimidin-3-yl)phen...)
Affinity DataIC50:  18nMAssay Description:Inhibition of CKITMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed