BDBM50188809 (S)-4-phenyl-8-((1S,2S)-2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one::CHEMBL378398

SMILES O=C1NC[C@@H](c2ccccc2)C11CCN(CC1)[C@H]1CCCC[C@H]1c1ccccc1

InChI Key InChIKey=MMAYPVADBNWURJ-HJOGWXRNSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50188809   

TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188809((S)-4-phenyl-8-((1S,2S)-2-phenyl-cyclohexyl)-2,8-d...)
Affinity DataEC50:  246nMAssay Description:Inhibition of [3H]glycine uptake at GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188809((S)-4-phenyl-8-((1S,2S)-2-phenyl-cyclohexyl)-2,8-d...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]NOP from human NOP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188809((S)-4-phenyl-8-((1S,2S)-2-phenyl-cyclohexyl)-2,8-d...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]naloxone from mu opioid receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188809((S)-4-phenyl-8-((1S,2S)-2-phenyl-cyclohexyl)-2,8-d...)
Affinity DataEC50:  3.96E+4nMAssay Description:Inhibition of [3H]glycine uptake at GlyT2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed