BDBM50188849 4-(4-fluoro-phenyl)-8-[1-(4-fluoro-phenyl)-cyclohexyl]-2,8-diaza-spiro[4.5]decan-1-one::CHEMBL377114::CHEMBL534940

SMILES Fc1ccc(cc1)C1CNC(=O)C11CCN(CC1)C1(CCCCC1)c1ccc(F)cc1

InChI Key InChIKey=IOYMPNIPADFRMW-UHFFFAOYSA-N

Data  5 IC50  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50188849   

TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188849(4-(4-fluoro-phenyl)-8-[1-(4-fluoro-phenyl)-cyclohe...)
Affinity DataEC50: >3.00E+4nMAssay Description:Inhibition of [3H]glycine uptake at GlyT2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188849(4-(4-fluoro-phenyl)-8-[1-(4-fluoro-phenyl)-cyclohe...)
Affinity DataEC50:  56nMAssay Description:Inhibition of [3H]glycine uptake at GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188849(4-(4-fluoro-phenyl)-8-[1-(4-fluoro-phenyl)-cyclohe...)
Affinity DataIC50:  7.80E+3nMAssay Description:Displacement of [3H]naloxone from mu opioid receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188849(4-(4-fluoro-phenyl)-8-[1-(4-fluoro-phenyl)-cyclohe...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]NOP from human NOP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188849(4-(4-fluoro-phenyl)-8-[1-(4-fluoro-phenyl)-cyclohe...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of hERG potassium channel expressed in CHO cells by whole cell patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188849(4-(4-fluoro-phenyl)-8-[1-(4-fluoro-phenyl)-cyclohe...)
Affinity DataEC50: >3.00E+4nMAssay Description:Inhibition of [3H]glycine uptake at GlyT2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188849(4-(4-fluoro-phenyl)-8-[1-(4-fluoro-phenyl)-cyclohe...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]naloxone from mu opioid receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188849(4-(4-fluoro-phenyl)-8-[1-(4-fluoro-phenyl)-cyclohe...)
Affinity DataEC50:  95nMAssay Description:Inhibition of [3H]glycine uptake at GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188849(4-(4-fluoro-phenyl)-8-[1-(4-fluoro-phenyl)-cyclohe...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]NOP from human NOP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188849(4-(4-fluoro-phenyl)-8-[1-(4-fluoro-phenyl)-cyclohe...)
Affinity DataEC50:  95nMAssay Description:Inhibition of [3H]glycine uptake at GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed