BDBM50191511 2-{4-[4'-chloro-4-(2-oxo-pyrrolidin-1-yl)-biphenyl-2-ylmethoxy]-2-fluoro-phenyl}-1-cyclohexyl-1H-benzoimidazole-5-carboxylic acid::2-{4-[4'-chloro-4-(2-oxopyrrolidin-1-yl)biphenyl-2-ylmethoxy]-2-fluorophenyl}-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid::CHEMBL210297

SMILES OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ccc(OCc2cc(ccc2-c2ccc(Cl)cc2)N2CCCC2=O)cc1F

InChI Key InChIKey=NIBYCXOKANETJM-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50191511   

TargetRNA-directed RNA polymerase(Hepatitis C virus)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50191511(2-{4-[4'-chloro-4-(2-oxo-pyrrolidin-1-yl)-biphenyl...)
Affinity DataIC50:  61nMAssay Description:Inhibition of HCV 3a NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50191511(2-{4-[4'-chloro-4-(2-oxo-pyrrolidin-1-yl)-biphenyl...)
Affinity DataIC50:  6.40E+3nMAssay Description:Inhibition of HCV 2a NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50191511(2-{4-[4'-chloro-4-(2-oxo-pyrrolidin-1-yl)-biphenyl...)
Affinity DataIC50:  170nMAssay Description:Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50191511(2-{4-[4'-chloro-4-(2-oxo-pyrrolidin-1-yl)-biphenyl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of HIV reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50191511(2-{4-[4'-chloro-4-(2-oxo-pyrrolidin-1-yl)-biphenyl...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of HCV 2b NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1)TBA
LigandPNGBDBM50191511(2-{4-[4'-chloro-4-(2-oxo-pyrrolidin-1-yl)-biphenyl...)
Affinity DataIC50:  8.33E+7nMAssay Description:Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 minMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50191511(2-{4-[4'-chloro-4-(2-oxo-pyrrolidin-1-yl)-biphenyl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase subunit gamma-1(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50191511(2-{4-[4'-chloro-4-(2-oxo-pyrrolidin-1-yl)-biphenyl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of DNA polymerase gammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50191511(2-{4-[4'-chloro-4-(2-oxo-pyrrolidin-1-yl)-biphenyl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of DNA polymerase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1)TBA
LigandPNGBDBM50191511(2-{4-[4'-chloro-4-(2-oxo-pyrrolidin-1-yl)-biphenyl...)
Affinity DataIC50:  8.34E+7nMAssay Description:Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 minMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50191511(2-{4-[4'-chloro-4-(2-oxo-pyrrolidin-1-yl)-biphenyl...)
Affinity DataIC50:  62nMAssay Description:Inhibition of HCV 1a NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed