BDBM50191523 2-{4-[5-(4-chlorophenyl)-2-methylthiazol-4-ylmethoxy]phenyl}-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid::CHEMBL212583

SMILES Cc1nc(COc2ccc(cc2)-c2nc3cc(ccc3n2C2CCCCC2)C(O)=O)c(s1)-c1ccc(Cl)cc1

InChI Key InChIKey=GYIVTDQIAWKBFH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50191523   

TargetRNA-directed RNA polymerase(Hepatitis C virus)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50191523(2-{4-[5-(4-chlorophenyl)-2-methylthiazol-4-ylmetho...)
Affinity DataIC50:  170nMAssay Description:Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1)TBA
LigandPNGBDBM50191523(2-{4-[5-(4-chlorophenyl)-2-methylthiazol-4-ylmetho...)
Affinity DataIC50:  5.89E+6nMAssay Description:Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 minMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1)TBA
LigandPNGBDBM50191523(2-{4-[5-(4-chlorophenyl)-2-methylthiazol-4-ylmetho...)
Affinity DataIC50:  5.88E+6nMAssay Description:Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 minMore data for this Ligand-Target Pair
In DepthDetails Article