BDBM50191617 (R)-3-(ethyl(3-(5-fluoro-1H-indol-3-yl)propyl)amino)-8-fluoro-3,4-dihydro-2H-chromene-5-carboxamide::CHEMBL211393

SMILES CCN(CCCc1c[nH]c2ccc(F)cc12)[C@H]1COc2c(F)ccc(C(N)=O)c2C1

InChI Key InChIKey=PLUNBASRAODYBA-MRXNPFEDSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50191617   

TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50191617((R)-3-(ethyl(3-(5-fluoro-1H-indol-3-yl)propyl)amin...)
Affinity DataKi:  3.40nMAssay Description:Displacement of [3H]paroxetine from 5-HT transporter in Sprague-Dawley rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50191617((R)-3-(ethyl(3-(5-fluoro-1H-indol-3-yl)propyl)amin...)
Affinity DataKi:  34.9nMAssay Description:Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50191617((R)-3-(ethyl(3-(5-fluoro-1H-indol-3-yl)propyl)amin...)
Affinity DataIC50:  42.7nMAssay Description:Inhibition of [3H]5-HT uptake at human 5-HT transporter expressed in Jar cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50191617((R)-3-(ethyl(3-(5-fluoro-1H-indol-3-yl)propyl)amin...)
Affinity DataIC50:  135nMAssay Description:Agonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed