BDBM50192786 CHEMBL216976::N-((1R,2S,5R,7S)-5-carbamoylmethyl-adamantan-2-yl)-2-methyl-2-(5-morphlin-4-yl-pyridin-2-yloxy)-propionamide

SMILES CC(C)(Oc1ccc(cn1)N1CCOCC1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CC(N)=O)(C3)C2

InChI Key

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50192786   

Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192786(N-((1R,2S,5R,7S)-5-carbamoylmethyl-adamantan-2-yl)...)
Affinity DataIC50: 44nMAssay Description:Inhibition of human 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192786(N-((1R,2S,5R,7S)-5-carbamoylmethyl-adamantan-2-yl)...)
Affinity DataIC50: 51nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192786(N-((1R,2S,5R,7S)-5-carbamoylmethyl-adamantan-2-yl)...)
Affinity DataIC50: 444nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192786(N-((1R,2S,5R,7S)-5-carbamoylmethyl-adamantan-2-yl)...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human 11beta-HSD2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Mouse)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192786(N-((1R,2S,5R,7S)-5-carbamoylmethyl-adamantan-2-yl)...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of mouse 11beta-HSD2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed