BDBM50194071 3-(6-chloropyridin-3-yl)-6-aza-bicyclo[2.2.1]heptane::5-(6-Chloro-pyridin-3-yl)-2-aza-bicyclo[2.2.1]heptane::CHEMBL363973

SMILES Clc1ccc(cn1)C1CC2CC1CN2

InChI Key InChIKey=PUMYSIXHQPYXGX-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50194071   

TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
University Of Leicester

Curated by ChEMBL
LigandPNGBDBM50194071(3-(6-chloropyridin-3-yl)-6-aza-bicyclo[2.2.1]hepta...)
Affinity DataKi:  1.23nMAssay Description:Displacement of [3H]epibatidine from human recombinant alpha4beta2 nAChR in HEK293 cells by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
University Of Leicester

Curated by ChEMBL
LigandPNGBDBM50194071(3-(6-chloropyridin-3-yl)-6-aza-bicyclo[2.2.1]hepta...)
Affinity DataKi:  1.23nMAssay Description:Displacement of [3H]epibatidine from human recombinant alpha4beta2 nAChR in HEK293 cells by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50194071(3-(6-chloropyridin-3-yl)-6-aza-bicyclo[2.2.1]hepta...)
Affinity DataKi:  30nMAssay Description:Inhibition of [3H]-cytisine binding to Nicotinic acetylcholine receptor alpha4-beta2 of rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50194071(3-(6-chloropyridin-3-yl)-6-aza-bicyclo[2.2.1]hepta...)
Affinity DataKi: >38nMAssay Description:Inhibition of [3H]-Nicotine binding to Nicotinic acetylcholine receptor alpha4-beta2 of rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50194071(3-(6-chloropyridin-3-yl)-6-aza-bicyclo[2.2.1]hepta...)
Affinity DataKi:  3.30E+3nMAssay Description:Inhibition of [3H]-BTX binding to Nicotinic acetylcholine receptor alpha7 of rat hippocampal membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50194071(3-(6-chloropyridin-3-yl)-6-aza-bicyclo[2.2.1]hepta...)
Affinity DataKi:  3.30E+3nMAssay Description:Displacement of [125I-alpha]-Bungarotoxin from alpha-7 nAChR in rat hippocampal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed