BDBM50196521 CHEMBL3939100::US10167270, Example 00162::US10501435, Compound 11d

SMILES C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1ccccc1

InChI Key InChIKey=DCLFPHIXBNDNBF-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50196521   

TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Northwestern University Feinberg School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50196521(CHEMBL3939100 | US10167270, Example 00162 | US1050...)
Affinity DataIC50:  11nMpH: 5.0Assay Description:Inhibition of synthetic recombinant wild type GCase enzyme velaglucerase alfa (unknown origin) at pH 5 preincubated for 5 mins followed by addition o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Northwestern University Feinberg School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50196521(CHEMBL3939100 | US10167270, Example 00162 | US1050...)
Affinity DataIC50:  6.5nMpH: 5.9Assay Description:Inhibition of synthetic recombinant wild type GCase enzyme velaglucerase alfa (unknown origin) at pH 5.9 preincubated for 5 mins followed by addition...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Northwestern University Feinberg School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50196521(CHEMBL3939100 | US10167270, Example 00162 | US1050...)
Affinity DataIC50:  9.40nMpH: 7.0Assay Description:Inhibition of synthetic recombinant wild type GCase enzyme velaglucerase alfa (unknown origin) at pH 7 preincubated for 5 mins followed by addition o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Northwestern University Feinberg School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50196521(CHEMBL3939100 | US10167270, Example 00162 | US1050...)
Affinity DataIC50:  6.5nMAssay Description:The enzyme in GCase enzyme activity buffer (25 μL/well) was added to a 384-well black plate. The fluorescent probe 3 (25 nL/well, 50 nM final co...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Northwestern University Feinberg School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50196521(CHEMBL3939100 | US10167270, Example 00162 | US1050...)
Affinity DataIC50:  9.40nMAssay Description:The compounds in DMSO solution (0.5 μL/well) were transferred to a black 96-well plate (the final titration started from 100 μM, a 12 or 24...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Northwestern University Feinberg School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50196521(CHEMBL3939100 | US10167270, Example 00162 | US1050...)
Affinity DataIC50:  6.5nMAssay Description:pH = 5.9.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Northwestern University Feinberg School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50196521(CHEMBL3939100 | US10167270, Example 00162 | US1050...)
Affinity DataIC50:  9.40nMAssay Description:pH = 7.0.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Northwestern University Feinberg School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50196521(CHEMBL3939100 | US10167270, Example 00162 | US1050...)
Affinity DataIC50:  10.5nMAssay Description:The compounds in DMSO solution (0.5 μL/well) were transferred to a black 96-well plate (the final titration started from 100 μM, a 12 or 24...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Northwestern University Feinberg School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50196521(CHEMBL3939100 | US10167270, Example 00162 | US1050...)
Affinity DataIC50:  6.5nMAssay Description:The compounds in DMSO solution (0.5 μL/well) were transferred to a black 96-well plate (the final titration started from 100 μM, a 12 or 24...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Northwestern University Feinberg School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50196521(CHEMBL3939100 | US10167270, Example 00162 | US1050...)
Affinity DataIC50:  10.5nMAssay Description:pH = 5.0.More data for this Ligand-Target Pair
In DepthDetails US Patent