BDBM50196523 CHEMBL3914158::US10167270, Compound 8g

SMILES C(Cc1cccnc1)Nc1nc(nc2ccccc12)-c1cccnc1

InChI Key InChIKey=UKYOLERGWNZMQS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50196523   

TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Northwestern University Feinberg School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50196523(CHEMBL3914158 | US10167270, Compound 8g)
Affinity DataIC50:  4.29E+3nMpH: 5.9Assay Description:Inhibition of synthetic recombinant wild type GCase enzyme velaglucerase alfa (unknown origin) at pH 5.9 preincubated for 5 mins followed by addition...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Northwestern University Feinberg School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50196523(CHEMBL3914158 | US10167270, Compound 8g)
Affinity DataIC50:  4.29E+3nMAssay Description:The enzyme in GCase enzyme activity buffer (25 μL/well) was added to a 384-well black plate. The fluorescent probe 3 (25 nL/well, 50 nM final co...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Northwestern University Feinberg School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50196523(CHEMBL3914158 | US10167270, Compound 8g)
Affinity DataIC50:  5.01E+3nMAssay Description:The enzyme in GCase enzyme activity buffer (25 μL/well) was added to a 384-well black plate. The fluorescent probe 3 (25 nL/well, 50 nM final co...More data for this Ligand-Target Pair
In DepthDetails US Patent