BDBM50200094 2-amino-1,9-dihydro-6H-purin-6-one::CHEMBL219568::Gua::guanine

SMILES Nc1nc2nc[nH]c2c(=O)[nH]1

InChI Key InChIKey=UYTPUPDQBNUYGX-UHFFFAOYSA-N

Data  2 KI  3 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50200094   

TargetPurine nucleoside phosphorylase(Rattus norvegicus)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50200094(2-amino-1,9-dihydro-6H-purin-6-one | CHEMBL219568 ...)
Affinity DataKi:  5.00E+3nMAssay Description:Tested for its ability to inhibit calf spleen purine nucleoside phosphorylase (PNP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50200094(2-amino-1,9-dihydro-6H-purin-6-one | CHEMBL219568 ...)
Affinity DataKi:  5.00E+3nMAssay Description:Competitive inhibition of human erythrocyte purine nucleoside phosphorylase assessed as inhibition of guanosine phosphorylysis after 30 mins by Linew...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
University Of Warsaw

Curated by ChEMBL
LigandPNGBDBM50200094(2-amino-1,9-dihydro-6H-purin-6-one | CHEMBL219568 ...)
Affinity DataKd:  160nMAssay Description:Binding affinity to calf recombinant PNP expressed in Escherichia coli BL21 (DE3) by fluorimetric titration analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
University Of Warsaw

Curated by ChEMBL
LigandPNGBDBM50200094(2-amino-1,9-dihydro-6H-purin-6-one | CHEMBL219568 ...)
Affinity DataKd:  120nMAssay Description:Binding affinity to calf recombinant PNP expressed in Escherichia coli BL21 (DE3) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetShiga toxin subunit A(Shigella dysenteriae)
TBA

Curated by ChEMBL
LigandPNGBDBM50200094(2-amino-1,9-dihydro-6H-purin-6-one | CHEMBL219568 ...)
Affinity DataIC50:  1.15E+4nMAssay Description:Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit in African green monkey Vero cells assessed as inhibition of Stx-induced cytotoxicity...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase(Escherichia coli (strain K12))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50200094(2-amino-1,9-dihydro-6H-purin-6-one | CHEMBL219568 ...)
Affinity DataKd:  3.80E+4nMAssay Description:Binding affinity to GST-tagged Escherichia coli HPPK expressed in Escherichia coli by SPR assay based alternative equilibrium affinity method in pres...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50200094(2-amino-1,9-dihydro-6H-purin-6-one | CHEMBL219568 ...)
Affinity DataIC50:  5.00E+3nMAssay Description:Compound was tested for inhibition of purine nucleoside phosphorylase using human erythro lysateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRicin(Ricinus communis)
University Of Texas

Curated by ChEMBL
LigandPNGBDBM50200094(2-amino-1,9-dihydro-6H-purin-6-one | CHEMBL219568 ...)
Affinity DataIC50:  9.00E+5nMAssay Description:Inhibitory concentration against Enzymatic A chain of ricin (RTA) using Artemia salina ribosomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed