BDBM50204295 CHEMBL3944381

SMILES N[C@H]1CCCC[C@H]1Nc1nc(-c2cnn3ccccc23)c2C(=O)NCc2c1C#N

InChI Key InChIKey=ZWGTZVUZDIHLON-JKSUJKDBSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50204295   

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50204295(CHEMBL3944381)
Affinity DataEC50:  9nMAssay Description:Inhibition of SYK in TgM-stimulated human Ramos cells expressing RA1/GFP-tagged BLNK assessed as reduction in RA1/GFP-tagged BLNK phosphorylation pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50204295(CHEMBL3944381)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human C-terminal 6His-tagged SYK (356 to 635 residues) expressed in Sf9 insect cells using 5-carboxyfluorescein(FAM)-EEPLYWSFPAKKK-NH2 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed