BDBM50206491 1-beta-D-arabinofuranosyl-5-(2-bromovinyl)uracil::5-((E)-2-Bromo-vinyl)-1-((2R,3S,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-4-hydroxy-1H-pyrimidin-2-one::CHEMBL70046::SORIVUDINE

SMILES OC[C@H]1O[C@H]([C@@H](O)[C@@H]1O)n1cc(C=CBr)c(=O)[nH]c1=O

InChI Key InChIKey=GCQYYIHYQMVWLT-BDNRQGISSA-N

Data  1 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50206491   

TargetThymidine kinase 2, mitochondrial(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM50206491(1-beta-D-arabinofuranosyl-5-(2-bromovinyl)uracil |...)
Affinity DataKi:  1.04E+4nMAssay Description:Inhibition of thymidine kinase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine kinase(Varicella-zoster virus (strain Dumas) (HHV-3) (Hum...)
University Of Ferrara

Curated by ChEMBL
LigandPNGBDBM50206491(1-beta-D-arabinofuranosyl-5-(2-bromovinyl)uracil |...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of VZV TK assessed as [methyl-3H]dThd phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine kinase, cytosolic(Homo sapiens (Human))
University Of Ferrara

Curated by ChEMBL
LigandPNGBDBM50206491(1-beta-D-arabinofuranosyl-5-(2-bromovinyl)uracil |...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of human TK1 assessed as [methyl-3H]dThd phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDeoxynucleoside kinase(Drosophila melanogaster)
University Of Ferrara

Curated by ChEMBL
LigandPNGBDBM50206491(1-beta-D-arabinofuranosyl-5-(2-bromovinyl)uracil |...)
Affinity DataIC50:  2.80E+4nMAssay Description:Inhibition of Drosophila melanogaster dNK assessed as [methyl-3H]dThd phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine kinase(Human herpesvirus 1 (strain SC16) (HHV-1) (Human h...)
University Of Ferrara

Curated by ChEMBL
LigandPNGBDBM50206491(1-beta-D-arabinofuranosyl-5-(2-bromovinyl)uracil |...)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of HSV1 TK assessed as [methyl-3H]dThd phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine kinase 2, mitochondrial(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM50206491(1-beta-D-arabinofuranosyl-5-(2-bromovinyl)uracil |...)
Affinity DataIC50:  4.30E+4nMAssay Description:Inhibition of human TK2 assessed as [methyl-3H]dThd phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed