BDBM50208823 6,11-dihydrothiochromeno[4,3-b]indole::CHEMBL180917::PD-146176

SMILES C1Sc2ccccc2-c2[nH]c3ccccc3c12

InChI Key InChIKey=ZGOOPZVQMLHPFM-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50208823   

TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM50208823(6,11-dihydrothiochromeno[4,3-b]indole | CHEMBL1809...)
Affinity DataKi:  3.81E+3nMAssay Description:Competitive inhibition of human 15-LOX-1 assessed as reduction in conversion of linoleic acid to 13(S)-HpODE incubated for 10 mins followed by linole...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM50208823(6,11-dihydrothiochromeno[4,3-b]indole | CHEMBL1809...)
Affinity DataKi:  3.81E+3nMAssay Description:Competitive inhibition of human 15-LOX1 using linoleic acid as substrate after 10 mins by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM50208823(6,11-dihydrothiochromeno[4,3-b]indole | CHEMBL1809...)
Affinity DataIC50:  3.81E+3nMAssay Description:Inhibition of rabbit reticulocyte 15-LOX using [14C]-linoleic acid as substrate preincubated for 15 mins followed by substrate addition by RP-HPLC an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM50208823(6,11-dihydrothiochromeno[4,3-b]indole | CHEMBL1809...)
Affinity DataIC50:  1.12E+3nMAssay Description:Inhibition of 15LOX in rabbit reticulocytes by EIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM50208823(6,11-dihydrothiochromeno[4,3-b]indole | CHEMBL1809...)
Affinity DataIC50:  810nMAssay Description:Inhibition of human 12/15-LOX expressed in HEK293 cells after 30 mins by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed