BDBM50210167 CHEMBL3917405
SMILES ONC(=O)CCCCCCOc1ccc2Nc3nccc(n3)-c3cccc(COC\C=C\COCc1c2)c3
InChI Key InChIKey=IYBYMTCQQMFOHB-AATRIKPKSA-N
Data 11 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 50210167
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of human JAK3 JH1 catalytic domain (I781 to S1124 residues) expressed in mammalian expression system by KINOMEScan assayMore data for this Ligand-Target Pair
Affinity DataIC50: 930nMAssay Description:Inhibition of human recombinant N-terminal His-tagged HDAC11 (1 to 347 residues) expressed in baculovirus infected insect cells preincubated with enz...More data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 2.17E+3nMAssay Description:Inhibition of full length human recombinant C-terminal His-tagged HDAC3 (1 to 428 residues)/N-terminal GST-tagged NCOR2 (395 to 489 residues) express...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Inhibition of JAK2 (unknown origin) preincubated for 20 mins followed by [33P]ATP addition measured after 120 mins by Hotspot assayMore data for this Ligand-Target Pair
Affinity DataIC50: 222nMAssay Description:Inhibition of full length human recombinant C-terminal FLAG/His-tagged HDAC1 (1 to 482 residues) expressed in sf21 cells preincubated with enzyme fol...More data for this Ligand-Target Pair
Affinity DataIC50: 2.10nMAssay Description:Inhibition of full length human recombinant N-terminal GST-tagged HDAC6 (1 to 1215 residues) expressed in sf9 cells preincubated with enzyme followed...More data for this Ligand-Target Pair
Affinity DataIC50: 740nMAssay Description:Inhibition of human recombinant C-terminal His-tagged HDAC8 (1 to 377 residues) expressed in insect cells preincubated with enzyme followed by fluoro...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of human PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system by KINOMEScan assayMore data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of human TYK2 (V877 to C1187 residues) expressed in mammalian expression system by KINOMEScan assayMore data for this Ligand-Target Pair
Affinity DataIC50: 49nMAssay Description:Inhibition of full length human recombinant C-terminal GST-tagged HDAC2 (1 to 488 residues) expressed in insect cells preincubated with enzyme follow...More data for this Ligand-Target Pair
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Inhibition of HDAC10 (unknown origin) preincubated with enzyme followed by fluorogenic Arg-His-Lys-Lys(Ac)-AMC substrate addition measured after 2 hr...More data for this Ligand-Target Pair