BDBM50211972 CHEMBL233823::N-(3-chloro-4-(trifluoromethyl)phenyl)-1-(2-(pyridin-4-yl)ethyl)-1H-pyrazole-5-carboxamide

SMILES FC(F)(F)c1ccc(NC(=O)c2ccnn2CCc2ccncc2)cc1Cl

InChI Key InChIKey=LMEHSVKTVLMKTO-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50211972   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chemical Diversity

Curated by ChEMBL
LigandPNGBDBM50211972(CHEMBL233823 | N-(3-chloro-4-(trifluoromethyl)phen...)
Affinity DataKi:  160nMAssay Description:Displacement of [32P]ATP from human VEGFR2 after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chemical Diversity

Curated by ChEMBL
LigandPNGBDBM50211972(CHEMBL233823 | N-(3-chloro-4-(trifluoromethyl)phen...)
Affinity DataKi:  170nMAssay Description:Inhibition of VEGFR2 assessed as inhibition of phosphorylation in presence of 2 uM ATP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Chemical Diversity

Curated by ChEMBL
LigandPNGBDBM50211972(CHEMBL233823 | N-(3-chloro-4-(trifluoromethyl)phen...)
Affinity DataIC50:  980nMAssay Description:Inhibition of VEGFR1 assessed as inhibition of phosphorylation in presence of 2 uM ATP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chemical Diversity

Curated by ChEMBL
LigandPNGBDBM50211972(CHEMBL233823 | N-(3-chloro-4-(trifluoromethyl)phen...)
Affinity DataIC50:  95nMAssay Description:Inhibition of VEGFR2 assessed as inhibition of phosphorylation in human 293 cells by cell-based ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chemical Diversity

Curated by ChEMBL
LigandPNGBDBM50211972(CHEMBL233823 | N-(3-chloro-4-(trifluoromethyl)phen...)
Affinity DataIC50:  180nMAssay Description:Inhibition of VEGFR2 assessed as inhibition of phosphorylation in presence of 2 uM ATP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed