BDBM50211979 CHEMBL399605::N-(4-tert-butylphenyl)-1-(2-(pyridin-4-yl)ethyl)-1H-pyrazole-5-carboxamide

SMILES CC(C)(C)c1ccc(NC(=O)c2ccnn2CCc2ccncc2)cc1

InChI Key InChIKey=AGXYJGOJFCYJET-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50211979   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chemical Diversity

Curated by ChEMBL
LigandPNGBDBM50211979(CHEMBL399605 | N-(4-tert-butylphenyl)-1-(2-(pyridi...)
Affinity DataKi:  130nMAssay Description:Inhibition of VEGFR2 assessed as inhibition of phosphorylation in presence of 2 uM ATP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chemical Diversity

Curated by ChEMBL
LigandPNGBDBM50211979(CHEMBL399605 | N-(4-tert-butylphenyl)-1-(2-(pyridi...)
Affinity DataKi:  140nMAssay Description:Displacement of [32P]ATP from human VEGFR2 after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chemical Diversity

Curated by ChEMBL
LigandPNGBDBM50211979(CHEMBL399605 | N-(4-tert-butylphenyl)-1-(2-(pyridi...)
Affinity DataIC50:  33nMAssay Description:Inhibition of VEGFR2 assessed as inhibition of phosphorylation in human 293 cells by cell-based ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chemical Diversity

Curated by ChEMBL
LigandPNGBDBM50211979(CHEMBL399605 | N-(4-tert-butylphenyl)-1-(2-(pyridi...)
Affinity DataIC50:  42nMAssay Description:Inhibition of VEGFR2 assessed as inhibition of phosphorylation in presence of 2 uM ATP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Chemical Diversity

Curated by ChEMBL
LigandPNGBDBM50211979(CHEMBL399605 | N-(4-tert-butylphenyl)-1-(2-(pyridi...)
Affinity DataIC50:  590nMAssay Description:Inhibition of VEGFR1 assessed as inhibition of phosphorylation in presence of 2 uM ATP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed