BDBM50214685 1-[(R)-2-{4-[2-((S)-1-amino-3-methylbutyl)-4-trifluoromethylphenyl]-piperazin-1-yl}-1-(4-dichlorobenzyl)-2-oxoethyl]pyrrolidin-2-one::CHEMBL439560

SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)N1CCCC1=O)C(F)(F)F

InChI Key InChIKey=GWQJQMUYAJRYAV-AZGAKELHSA-N

Data  5 KI  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50214685   

TargetMelanocortin receptor 4(Mus musculus)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50214685(1-[(R)-2-{4-[2-((S)-1-amino-3-methylbutyl)-4-trifl...)
Affinity DataKi:  5.5nMAssay Description:Binding affinity to C57BL/6J mouse MC4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Rattus norvegicus)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50214685(1-[(R)-2-{4-[2-((S)-1-amino-3-methylbutyl)-4-trifl...)
Affinity DataKi:  9.10nMAssay Description:Binding affinity to rat MC4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50214685(1-[(R)-2-{4-[2-((S)-1-amino-3-methylbutyl)-4-trifl...)
Affinity DataKi:  11nMAssay Description:Displacement of [125I]NDP-MSH from MC4R receptor in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50214685(1-[(R)-2-{4-[2-((S)-1-amino-3-methylbutyl)-4-trifl...)
Affinity DataKi:  990nMAssay Description:Displacement of [125I]NDP-MSH from MC5R receptor in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50214685(1-[(R)-2-{4-[2-((S)-1-amino-3-methylbutyl)-4-trifl...)
Affinity DataKi:  1.80E+3nMAssay Description:Displacement of [125I]NDP-MSH from MC3R receptor in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50214685(1-[(R)-2-{4-[2-((S)-1-amino-3-methylbutyl)-4-trifl...)
Affinity DataIC50:  510nMAssay Description:Agonist activity at human MC4 receptor in HEK293 cells assesed as inhibition of alpha-MSH stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50214685(1-[(R)-2-{4-[2-((S)-1-amino-3-methylbutyl)-4-trifl...)
Affinity DataEC50:  4.10E+3nMAssay Description:Agonist activity at ghrelin receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed