BDBM50216423 2-[2-oxo-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1,2-dihydro-indol-3-yl-idene]-malononitrile::CHEMBL376760

SMILES O=[#6]1-[#7]-c2ccc(cc2\[#6]-1=[#6](\C#N)C#N)S(=O)(=O)[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6]-[#8]-c1ccccc1

InChI Key InChIKey=QPUCXRHTRZYTHM-INIZCTEOSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50216423   

TargetCaspase-7(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50216423(2-[2-oxo-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl...)
Affinity DataIC50:  1.59E+3nMAssay Description:Inhibition of human recombinant caspase 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50216423(2-[2-oxo-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl...)
Affinity DataIC50:  1.83E+3nMAssay Description:Inhibition of human recombinant caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50216423(2-[2-oxo-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl...)
Affinity DataIC50:  272nMAssay Description:Inhibition of human recombinant caspase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50216423(2-[2-oxo-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human recombinant caspase 8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50216423(2-[2-oxo-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl...)
Affinity DataIC50:  407nMAssay Description:Inhibition of human recombinant caspase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed