BDBM50218703 2-[3-(3-methoxy-4-nitrophenyl)-11-oxo-10,11-dihydro-5Hdibenzo[b,e][1,4]diazepin-7-yl]-2-methyl-N-(4-morpholin-4-ylphenyl)propanamide::CHEMBL387787

SMILES COc1cc(ccc1N)-c1ccc2c(Nc3cc(ccc3NC2=O)C(C)(C)C(=O)Nc2ccc(cc2)N2CCOCC2)c1

InChI Key InChIKey=FNXFVMLVCXXTQM-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50218703   

TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50218703(2-[3-(3-methoxy-4-nitrophenyl)-11-oxo-10,11-dihydr...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant Chk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50218703(2-[3-(3-methoxy-4-nitrophenyl)-11-oxo-10,11-dihydr...)
Affinity DataEC50: >5.93E+4nMAssay Description:Antiproliferative activity against HeLa cells by MTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50218703(2-[3-(3-methoxy-4-nitrophenyl)-11-oxo-10,11-dihydr...)
Affinity DataEC50: >1.00E+4nMAssay Description:Cell cycle arrest in HeLa cells assessed as accumulation at G2/M phase by FACS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed