BDBM50220060 (14-dimethylaminomethyl-6H,13H-pyrazino[1,2-a;4,5-a']diindol-7-ylmethyl)-dimethyl-amine::CHEMBL203627

SMILES CN(C)Cc1c2Cn3c(Cn2c2ccccc12)c(CN(C)C)c1ccccc31

InChI Key InChIKey=PUDDOANNCQNPJM-UHFFFAOYSA-N

Data  4 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50220060   

TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50220060((14-dimethylaminomethyl-6H,13H-pyrazino[1,2-a;4,5-...)
Affinity DataKi:  5.40E+3nMAssay Description:Displacement of [3H]methyllycaconitine from alpha7 nAChR in tsA201 cells co-expressed with Ric3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholine receptor subunit alpha/beta/delta/gamma(Torpedo californica)
University Of W£Rzburg

Curated by ChEMBL
LigandPNGBDBM50220060((14-dimethylaminomethyl-6H,13H-pyrazino[1,2-a;4,5-...)
Affinity DataKi:  1.07E+4nMAssay Description:Displacement of (+/-)-[3H]epibatidine from muscle type nAChR of Torpedo californica in hepes bufferMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50220060((14-dimethylaminomethyl-6H,13H-pyrazino[1,2-a;4,5-...)
Affinity DataKi:  1.90E+4nMAssay Description:Displacement of [3H]methyllycaconitine from human alpha-7 in tsA201 cells coexpressed with 5HT3A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50220060((14-dimethylaminomethyl-6H,13H-pyrazino[1,2-a;4,5-...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]GR65630 from human 5HT3A receptor in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
University Of W£Rzburg

Curated by ChEMBL
LigandPNGBDBM50220060((14-dimethylaminomethyl-6H,13H-pyrazino[1,2-a;4,5-...)
Affinity DataEC50:  1.66E+4nMAssay Description:Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes bufferMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
University Of W£Rzburg

Curated by ChEMBL
LigandPNGBDBM50220060((14-dimethylaminomethyl-6H,13H-pyrazino[1,2-a;4,5-...)
Affinity DataEC50:  447nMAssay Description:Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed